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Search Results for " prolactin receptor "

Targets Recommended: Dopamine Receptor 5-HT Receptor Sodium Channel

13

抑制剂 & 化合物

1

天然产物

9

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T4008	Metergoline 甲麦角林,Methergoline,Liserdol	Dopamine Receptor; 5-HT Receptor; Sodium Channel	GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Metergoline (Methergoline) 是多巴胺激动剂和血清素拮抗剂。它是 h5-HT7受体的高亲和力配体，Ki 为 16 nM。它还是可逆神经 Na+通道抑制剂，用于研究季节性情绪障碍、催乳激素调节。
T7943	Fluphenazine decanoate	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Fluphenazine decanoate 是一种高度连续的多巴胺 D2受体阻滞剂，是一种长效吩噻嗪抗精神病药，用于精神分裂症的研究。
TP1937L1	RFRP-1 (human) acetate(311309-25-8 free base)	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	RFRP-1 (human) acetate(311309-25-8 free base) 是一种有效的内源性 NPFF 受体激动剂（NPFF2 和 NPFF1 的 EC50 值分别为 0.0011 和 29 nM）。它减弱离体大鼠和兔心肌细胞的收缩功能。降低心率、每搏输出量、射血分数和心输出量，并增加大鼠的血浆催乳素水平。 GnIH 同系物。
T24003	Disulergine CM 29717,CH 29717,CH 29-717
	Disulergine is a dopamine receptor agonist. It also prolactin release-inhibiting 8 alpha-amino-ergoline.
T75947	RFRP-1(human) TFA
	RFRP-1(human) TFA, an endogenous NPFF receptor agonist, exhibits potent activity with EC50 values of 0.0011 nM for NPFF2 and 29 nM for NPFF1. It significantly diminishes the contractile function of isolated rat and rabbit cardiac myocytes. Moreover, it decreases heart rate, stroke volume, ejection fraction, and cardiac output, while elevating plasma prolactin levels in rats.
T68551	Cabergoline diphosphate
	Cabergoline diphosphate is a dopamine D2 receptor agonist used for prolactinoma treatment. Cabergoline permits rapid and effective hormonal and tumor control by normalizing prolactin-producing pituitary adenomas levels.
T8775	Lisuride maleate R-(+)-LISURIDE HYDROGEN MALEATE
	Lisuride maleate is an agonist of Dopamine receptor and anti-Parkinson's agent. Displays high affinity for D2, D3 and D4 receptors along with 5-HT1A. Exhibits some 5-HT2B receptor antagonist properties. Decreases prolactin release; reduces inflammatory me
T81390	Prolactin-Releasing Peptide (1-31) (rat)
	Prolactin-Releasing Peptide (1-31) (rat) 通过减少禁食诱导的大鼠食物摄入，有效提升血浆LH、FSH及睾酮水平。
T81391	Prolactin-Releasing Peptide (12-31), rat
	Prolactin-Releasing Peptide (12-31), rat 为催乳素释放肽的一个段落，对 GPR10 受体具有高度亲和性，并能在转染了 PrRP 受体的 CHOK1 细胞中激发钙离子动员。
TP1937	RFRP-1(human) RFRP-1 (human)
	Potent endogenous NPFF receptor agonist (EC50 values are 0.0011 and 29 nM for NPFF2 and NPFF1, respectively). Attenuates contractile function of isolated rat and rabbit cardiac myocytes. Reduces heart rate, stroke volume, ejection fraction and cardiac out
T81598	Org OD 02-0 10-Ethenyl-19-norprogesterone	p38 MAPK	MAPK
	Org OD 02-0（10-Ethenyl-19-norprogesterone）为mPRα（膜孕酮受体α）特异性激动剂，IC50值为33.9 nM。该化合物能够激活MAPK活性，并且能抑制催乳素（PRL）的分泌。
T83756	S1H TFA Site 1-binding Helix
	S1H是一种人造肽类模拟物，模仿人类生长激素的第36至51个氨基酸，且为生长激素受体的拮抗剂。在溶液中呈现α-螺旋结构，并在100和200纳摩尔（nM）的浓度下，能降低SK-MEL-28和MALME-3M黑色素瘤细胞系以及IM-9 B细胞淋巴细胞中，由人类生长激素及泌乳素诱导的STAT5磷酸化。
TP1532	γ-2-MSH (41-58), amide
	Melanocortin (MC) 3-MSH (Melanocyte-Stimulating Hormone) is believed to signal through the MC 3 receptor. It induces a sustained increase in intracellular free calcium levels ([Ca2+]i) in a subpopulation of pituitary cells. Most of the cells responding to

化合物

Cat.No: T4008

Synonym: 甲麦角林,Methergoline,Liserdol

Target: Dopamine Receptor, 5-HT Receptor, Sodium Channel

Fluphenazine decanoate

Cat.No: T7943

Target: Dopamine Receptor

RFRP-1 (human) acetate(311309-25-8 free base)

Cat.No: TP1937L1

Target: Neuropeptide Y Receptor

Cat.No: T24003

Synonym: CM 29717,CH 29717,CH 29-717

RFRP-1(human) TFA

Cat.No: T75947

Cabergoline diphosphate

Cat.No: T68551

Lisuride maleate

Cat.No: T8775

Synonym: R-(+)-LISURIDE HYDROGEN MALEATE

Prolactin-Releasing Peptide (1-31) (rat)

Cat.No: T81390

Prolactin-Releasing Peptide (12-31), rat

Cat.No: T81391

Cat.No: TP1937

Synonym: RFRP-1 (human)

Cat.No: T81598

Synonym: 10-Ethenyl-19-norprogesterone

Target: p38 MAPK

Cat.No: T83756

Synonym: Site 1-binding Helix

γ-2-MSH (41-58), amide

Cat.No: TP1532

Cat. No.	Product Name	Target	Signaling Pathways
T14853	Cabergoline FCE-21336,卡麦角林	Dopamine Receptor; 5-HT Receptor; Autophagy	Autophagy; GPCR/G Protein; Neuroscience
	Cabergoline (FCE-21336) 是一种麦角衍生的多巴胺 D2亚类受体激动剂，高亲和力作用于D2、D3和5-HT2B 受体，Ki 分别为 0.7、1.5 和 1.2。

天然产物

Cat.No: T14853

Synonym: FCE-21336,卡麦角林

Target: Dopamine Receptor, 5-HT Receptor, Autophagy

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01053	Prolactin Receptor Protein, Human, Recombinant (His) hPRLrI,PRLR,MFAB,HPRL,prolactin receptor	Human	HEK293 Cells
	Prolactin Receptor Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is P16471-1.
TMPY-02434	Prolactin Receptor Protein, Rat, Recombinant (His) prolactin receptor,RATPRLR,MGC105486	Rat	HEK293 Cells
	Prolactin Receptor Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is P05710-1.
TMPY-02984	Prolactin Receptor Protein, Mouse, Recombinant (His) Pr-1,Pr-3,AI987712,prolactin receptor,Prlr...	Mouse	HEK293 Cells
	Prolactin Receptor Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is P07321.
TMPY-01566	Prolactin Receptor Protein, Mouse, Recombinant (His & hFc) prolactin receptor,Prlr,Pr-3,Pr-1,Prlr-rs1...	Mouse	HEK293 Cells
	Prolactin Receptor Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 52.5 kDa and the accession number is Q08501-1.
TMPJ-00347	PRLR Protein, Mouse, Recombinant (His) PRLR,PRL-R,Prolactin receptor,Prolacti...	Mouse	HEK293 Cells
	PRLR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 33-40 KDa and the accession number is Q08501.
TMPJ-00346	PRLR Protein, Mouse, Recombinant (hFc) Prolactin R,Prlr,Prolactin receptor	Mouse	HEK293 Cells
	PRLR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 62-88 KDa and the accession number is Q08501.
TMPK-00547	PRLR Protein, Cynomolgus, Recombinant (His) Prolactin R,HPRL,MFAB,PRL-R	Cynomolgus	HEK293 Cells
	Prolactin receptor (PRLR) is highly expressed in a subset of human breast cancer and prostate cancer, which makes it a potential target for cancer treatment. In clinical trials, the blockade of PRLR was shown to be safe but with poor efficacy. It is therefore urgent to develop new therapies against PRLR target. Bispecific antibodies (BsAbs) could guide immune cells toward tumor cells, and produced remarkable effects in some cancers. PRLR Protein, Cynomolgus, Recombinant (His) is expressed in HEK...
TMPK-01375	PRLR Protein, Canine, Recombinant (hFc) PRL-R,Prolactin R,MFAB,HPRL	Canine	HEK293 Cells
	Prolactin receptor (PRLR) is highly expressed in a subset of human breast cancer and prostate cancer, which makes it a potential target for cancer treatment. In clinical trials, the blockade of PRLR was shown to be safe but with poor efficacy. It is therefore urgent to develop new therapies against PRLR target. Bispecific antibodies (BsAbs) could guide immune cells toward tumor cells, and produced remarkable effects in some cancers. PRLR Protein, Canine, Recombinant (hFc) is expressed in HEK293 ...
TMPH-02274	JAK2 Protein, Human, Recombinant (His)	Human	E. coli
	Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple int...

重组蛋白

Prolactin Receptor Protein, Human, Recombinant (His)

Cat.No: TMPY-01053

Species: Human

Expression System: HEK293 Cells

Prolactin Receptor Protein, Rat, Recombinant (His)

Cat.No: TMPY-02434

Species: Rat

Expression System: HEK293 Cells

Prolactin Receptor Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02984

Species: Mouse

Expression System: HEK293 Cells

Prolactin Receptor Protein, Mouse, Recombinant (His & hFc)

Cat.No: TMPY-01566

Species: Mouse

Expression System: HEK293 Cells

PRLR Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00347

Species: Mouse

Expression System: HEK293 Cells

PRLR Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00346

Species: Mouse

Expression System: HEK293 Cells

PRLR Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00547

Species: Cynomolgus

Expression System: HEK293 Cells

PRLR Protein, Canine, Recombinant (hFc)

Cat.No: TMPK-01375

Species: Canine

Expression System: HEK293 Cells

JAK2 Protein, Human, Recombinant (His)

Cat.No: TMPH-02274

Species: Human

Expression System: E. coli

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